Recent studies found that circATP5B and circCHAF1A were upregulated in GSCs, and promoted GSC proliferation through miR-185-5p/HOXB5 and miR-211-5p/HOXC8 axes, respectively.51,52 In addition, circRNA can mediate the cell proliferation of Glioma through activation of EGFR–STAT3 signaling. The gene discussed is EGFR; the disease is glioma.