ATXN1 and glioma: circ-Mmbl can also eliminate excess MBL by binding to MBL.28 CircRNA can facilitate the interaction between DNA, RNA, and RBP to perform biological functions by binding to related proteins.29 Liu et al. found that splicing factor SRSF10 can bind to Alu elements on both sides of the circ-ATXN1 pre-mRNA,30 thus promoting the generation of circ-ATXN1 and the proliferation, migration, and tube-forming capacity of glioma-exposed endothelial cells (GECs) via circ-ATXN1/miR-526b-3p/MMP2/VEGFA pathway.