MTOR and central nervous system cancer: Silencing circZNF292 can block the cell cycle in the S/G2/M phase, inhibiting glioma cell migration and tube formation.56 Further, circPCMTD1 and hsa_circ_0037251 promote glioma cell proliferation and metastasis by regulating the mammalian target of rapamycin (mTOR) pathway via sponging of miR-224-5p and miR-1229-3p, respectively.57 Oncogenic circRNAs have also been reported in MBs, circ-SKA3, circ-DTL, and circ_63706 promoted the proliferation, migration, and invasion of medulloblastoma cells by regulating gene expression.58,59