HK2 and central nervous system cancer: circPOSTN was overexpressed in glioma tissues and induced tumor cell proliferation by targeting the miR-361-5p/TPX2 axis.71 A study showed that circPOSTN or TPX2 knockdown could inhibit HK2 expression levels, indicating that circPOSTN might be involved in glioma progression by affecting aerobic glycolysis.71 Therefore, inhibition of aerobic glycolysis may be a promising anti-tumor therapy.