circFOXO3 can serve as a competitive ceRNA to upregulate NFAT5 by sponging miR-138-5p and miR-432-5p, which enhance glioma cell migration and invasion.53 Additionally, circSMO742 contributes to mediating cell proliferation and invasion by targeting miR-338-3p and upregulating smoothened (SMO) expression levels.54 A recent study showed that circNALCN was downregulated in Glioma and inhibited tumorigenesis and invasion by targeting miR-493.55 circZNF292 can interact with other related genes, including cyclin A, VEGFR, and EGFR, to promote tumorigenesis and invasion. Here, SMO is linked to central nervous system cancer.