Regarding cytotoxic T lymphocytes, we observed that as the degree of obesity increased (TBF), memory T lymphocytes (CD8+CD45RO+) also increased (Table 3 & Fig. 2C) but naïve T lymphocytes (CD8+CD45RA+) decreased (Table 3 & Fig. 2D). This evidence concerns the gene CD8A and obesity due to melanocortin 4 receptor deficiency.