CD8A and obesity due to melanocortin 4 receptor deficiency: In the class 3 obesity group, we found positive correlations between leukocytes and VF and CRP (Figs. 4A & 4B) and between granulocytes and CRP (Fig. 4C), and a negative correlation between CD8+CD45RA+CD45RO+ T lymphocytes and VF (Fig. 4D).