As the TBF percentage (severity of obesity) increases, CD4+, CD4+CD62-, and CD8+CD45RO+ T lymphocytes increase in peripheral blood, demonstrating the existence of an inflammatory process at the peripheral level that is also associated with other variables such as WC, BMI, CRP, leukocytes, and age. This evidence concerns the gene CD4 and obesity due to melanocortin 4 receptor deficiency.