SIRT6 and cancer: Another such example is SIRT6, which is elevated in chronically exercised individuals and performs both protective and pejorative actions in relation to cancer (Yang et al., 2020; Song et al., 2022); recommendations with regards to NSPAN should consider which effect is more important (protective/pejorative) with regards to the different pathways regulated by EIC and CRM in establishing minimal and optimal thresholds across modalities.