In particular, NF-κB chronic activation has been implicated in the pejoration of symptoms of Alzheimer’s disease and neuroinflammation—a risk factor for neurodegenerative diseases and depression (Dolatschahi et al., 2021; Capece et al., 2022); and NF-κB is involved in contradictory functions such as cell survival and neurodegeneration (Mincheva-Tasheva et al., 2013): “the same stimulus produces opposite responses by activating NF-κB in different cell types” (p. 187). Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.