The proposed oncogenic effect of catecholamines is mediated by the Beta 2 adrenergic receptor (ADRB2) enhancing tumour growth and angiogenesis by activation of the c‐AMP protein kinase A (PKA) pathway with subsequent elevation of matrix metalloproteinases and VEGF, as well as p53 breakdown and DNA damage.32 The gene discussed is VEGFA; the disease is neoplasm.