A locus near Paired Box 8 (PAX8), a gene involved in sleep efficiency, diastolic blood pressure, development, and vulnerability to neurodegenerative diseases (Elliott et al., 2018; Foo et al., 2021b; Jones et al., 2019), showed an association with the majority of functional connectivity measures, including multilayer and multiplex clustering, as well as all single-layer measures. Here, PAX8 is linked to neurodegenerative disease.