Immunohistochemical staining for platelets (CD42b) revealed a physiologic pattern of their distribution confined to the vessels in the majority of the controls but only in one-third of the patients with COVID-19 (63% vs 31%, respectively; P = .028; Figure 1A); in 4 COVID-19 cases (14%) and 2 control cases (8%), single scattered megakaryocyte equivalents were detectable (P = .674). This evidence concerns the gene GP1BA and COVID-19.