Human umbilical cord mesenchymal stem cells (hUCMSCs)-derived sEVs-miR-9-3p exert anti-tumor effects by downregulating the tumor promoter gene endothelial cell-specific molecule-1 (ESM-1), leading to reduced BC cell viability, migration, invasion, and enhanced apoptosis (Xiang et al., 2022). The gene discussed is ESM1; the disease is breast cancer.