Ranking of the regulator specificity scores of the fibroblast subpopulations revealed that NR2F2 was the most specific regulator of both the CXCR4+PMAIP1+ Fib and MT1M+ Fib subpopulations and has the ability to promote tumor cell proliferation, epithelial-mesenchymal transition, and invasive features (Mauri et al., 2021) (Figure 3G). This evidence concerns the gene NR2F2 and neoplasm.