C. albicans mediates the up-regulation of macrophage glycolytic pathway, and up-regulates the expression and secretion of IL-7, and then induces type 3 intrinsic lymphocytes (ILC3) to express high levels of IL-22 through AhR and STAT3 pathways, which aggravates the progression of colorectal cancer. This evidence concerns the gene STAT3 and colorectal cancer.