Although interferon-gamma release assays (IGRAs) have been considered as a useful method for diagnosis of M.tb infection and an auxiliary method for diagnosis of active TB (Gao et al., 2015; Getahun et al., 2015), the sensitivity of IGRAs is reduced among immunocompromised individuals (Jung et al., 2012; Pan et al., 2015), including HIV-infected patients, which limits the clinical application of this methodology (Cattamanchi et al., 2011; Metcalfe et al., 2011; Santin et al., 2012). Here, IFNG is linked to tuberculosis.