Overall, the correlation coefficient, including both Ki67 and PCNA, showed that most BMPs, BMP receptors and antagonists were negatively correlated with the proliferation status of breast cancer with the leading genes: GDF10, BMP4, TGFBR2, TGFBR3 and GDF3, whilst DAND5, BMP8B, BMPR1A, Smad2 and SOST were positively correlated with proliferation markers in the TCGA breast cancer cohort. The gene discussed is SMAD2; the disease is breast carcinoma.