The resveratrol anti-inflammatory effects result the suppression of NF-κB and NF-κB regulated gene products. Resveratrol can also lessen ER stress in the granulosa cells (GCs) by changing the expression of the genes responsible for the unfolding protein response process. ER stress is a potential therapeutic target for patients with PCOS. This evidence concerns the gene NFKB1 and polycystic ovary syndrome.