CD40LG and congenital toxoplasmosis: Although in many contexts, declining exposure to T. gondii commonly lead to a lower incidence of congenital toxoplasmosis due to fewer seroconversions in pregnancy, some studies have observed an unexpected increase in congenital toxoplasmosis incidence or IgM prevalence despite declining seroprevalence (Edelhofer and Prossinger, 2010; Mongua-Rodriguez et al., 2013).