It has been proven that upregulation of CD8+ T cells contributes to autoimmunity driven demyelination and axonal damage (Bitsch et al., 2000; Friese and Fugger, 2009; Gilmore et al., 2020; Lind et al., 2021), while highly differentiated effector CD8+ TEMRA cells have been associated with neuroinflammation and degeneration (Northfield et al., 2007; Benveniste and Allenbach, 2019). Here, CD8A is linked to Autoimmunity.