For Ruminiclostridium, a recent study found that intranasal delivery of rural dusts decreased eosinophils and plasma IgE levels in mice and contributed to a recovery of gut microbiota diversity and Ruminiclostridium in a mouse model, suggesting that exposure to Ruminiclostridium may promote allergy management (Yang et al., 2022). The gene discussed is IGHE; the disease is allergic disease.