NLRP3 and Insulin resistance: Second, the physio-affective phenome of Long COVID is associated with neuro-oxidative stress toxicity (OSTOX) and decreased antioxidant defenses (ANTIOX; Maes, 2011b; Maes et al., 2022b; Al-Hakeim et al., 2023a), activation of the NLRP3 inflammasome, inflammation as indicated by increased levels of C-reactive protein (CRP), and increased insulin resistance as assessed with the Homeostatic Model Assessment Index 2-insulin resistance (HOMA2-IR; Al-Hakeim et al., 2023b).