Increased production of TRYCATs appears to be a characteristic of acute inflammatory conditions, such as critical acute COVID-19 infection (Almulla et al., 2023) and IFN-induced depression (Bonaccorso et al., 2002), as opposed to mild chronic inflammatory conditions, such as depression, schizophrenia, and Alzheimer’s disease (Almulla et al., 2022a,c,d). The gene discussed is IFNA1; the disease is schizophrenia.