Increased production of TRYCATs appears to be a characteristic of acute inflammatory conditions, such as critical acute COVID-19 infection (Almulla et al., 2023) and IFN-induced depression (Bonaccorso et al., 2002), as opposed to mild chronic inflammatory conditions, such as depression, schizophrenia, and Alzheimer’s disease (Almulla et al., 2022a,c,d). Here, IFNA1 is linked to major depressive disorder.