Increased production of TRYCATs appears to be a characteristic of acute inflammatory conditions, such as critical acute COVID-19 infection (Almulla et al., 2023) and IFN-induced depression (Bonaccorso et al., 2002), as opposed to mild chronic inflammatory conditions, such as depression, schizophrenia, and Alzheimer’s disease (Almulla et al., 2022a,c,d). This evidence concerns the gene IFNA1 and Alzheimer disease.