PINK1 and prion disease: As we found that CL externalization increased the mitophagy level to clean damaged mitochondria induced by PrP106−126 and had a positive effect on PINK1 and DRP1 recruitment, the uncertain effects of CL externalization induced by PrP106−126 prompted us to investigate the consequences of oxidative stress on mitochondrial dysfunction, which is widely reported in Prion disease (Milhavet et al., 2000).