HIF1A and neoplasm: Moreover, curcumin demonstrates its anti-tumor effects by disturbing several signaling pathways, such as ras, AKT, monoamine oxidase A/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α), signal transducers and activators of transcription 3 (STAT3), and vascular endothelial growth factor (VEGF) pathways [17,18,19,20].