Retinal sensitivity in macular cystoid edema (CME) patients without macular thickness was reduced during a randomized clinical study with the treatment group receiving an oral combination of desmin (300 mg/day) and troxerutin (300 mg/day) with Centella asiatica (30 mg/day) and Melilotus (160 mg/day) for 14 months compared with the control group (p<0.001). The gene discussed is DES; the disease is Cystoid macular dystrophy.