Prior studies have reported the existence of astrocytes and microglia around the amyloid plaques in AD (Varnum and Ikezu, 2012), as well as increased expression of different proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and free radicals in the blood samples and brain of AD patients (Akiyama et al., 2000; Ganguly et al., 2021). This evidence concerns the gene IL1B and Alzheimer disease.