ITGB2 and Alzheimer disease: Afterward, we inspected the expression of the top 10 hub genes (ARHGAP30, LAPTM5, ITGB2, DOCK2, TBXAS1, NCKAP1L, SLC7A7, SYK, LCP1, and C3AP1) of the module and found that they were all upregulated significantly (Figure 2G), comparing the AD group with the control group.