APOE and Alzheimer disease: It has been found that neuronal ApoE4 mediates the pathophysiology of AD may include: prevents lipid excretion; induces inflammation of microglia to damage neurons; participation in the occurrence of Tau pathology, etc.; and studies have confirmed that selective removal of ApoE4 from neurons significantly reduce Tau pathology, glial proliferation, neurodegeneration, neuronal hyperexcitability, and myelin deficiency (Koutsodendris et al., 2023).