Neuronal ApoE4 causes the onset of AD through a variety of pathophysiological mechanisms, including: stimulating microglia to induce neuroinflammation; directly leads to neuronal degeneration; participating in other signaling pathways mediating the production and aggregation of Aβ and Tau; preventing the excretion of lipids, causing lipid accumulation in cells, etc.; It can also reduce the formation of myelin sheaths by affecting the cholesterol transport of neurons, thus Induce AD pathology (Belloy et al., 2019; Blanchard et al., 2022; Dolgin, 2022). Here, MAPT is linked to Alzheimer disease.