In the Aβ-positive sample, 12.1% (n = 56) of CU participants, 36.1% (n = 100) of MCI and 73.9% (n = 68) of Alzheimer’s disease patients had at least one region of tau positivity (Fig. 2A, heatmap in Fig. 3A). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.