In monkeys, rats, mice, fish, flies and worms expression of human α-synuclein can mimic key features of Parkinson’s disease including progressive locomotor dysfunction, degeneration of dopaminergic and non-dopaminergic neurons, and α-synuclein aggregation (Feany and Bender, 2000; Masliah et al., 2000; Kirik et al., 2002, 2003; Lee et al., 2002; Lakso et al., 2003; O’Donnell et al., 2014). Here, SNCA is linked to Parkinson disease.