Of the 132 type 2 diabetes Knowledge Portal effector genes, we identified 18 (14%) as candidate effector genes for at least one phenotype, including ABCC8, KCNJ11, NKX2–2, G6PC2, PAM, HNF4A, SLC30A8, RFX6, PCSK1, and GLIS3. This evidence concerns the gene NKX2-2 and type 2 diabetes mellitus.