The nominated effector gene for mannose, GCKR, was shown to affect both lipids and carbohydrates, including sphingolipids, glycerolipids, and serine (key connecter of amino acids to lipids, carbohydrates)51, suggesting that lipids and carbohydrates pathways may play an important role in alcoholism, T2D and PD. Here, GCKR is linked to type 2 diabetes mellitus.