With regards to sarcomas, in humanized NOD-scid IL2Rγnull mice inoculated with human fibrosarcoma cells expressing FAP, the combination of anti-FAP-F19-ΔCD28/CD3ζ-CAR-T cells and PD-1 blockade demonstrated significant anti-tumor activity and improved survival [65]. The gene discussed is CD247; the disease is sarcoma.