Moreover, the role of ST2 and IL-33 in the regulation of pivotal inflammatory molecules pertinent to OvC, such as COX-2 (cyclooxygenase-2), p38, IL-1β, p65, and IL-6, the rate-limiting enzyme applied in the underlying intracellular signaling pathways, was also investigated in ovarian cancer progression and histopathological/clinical features. This evidence concerns the gene PTGS2 and ovarian cancer.