It was reported that NLRP3/caspase-1-dependent pyroptosis participated in the cerebral ischemia/reperfusion injury and cognitive decline after focal cortical infarction, NLRP3 inhibitor and caspase-1 inhibitor could improve the symptoms, respectively (Sun et al., 2020; Dong et al., 2022). This evidence concerns the gene CASP1 and brain ischemia.