Poh et al. (2021) observed increased expression of inflammasome components and precursor IL-1β in the brain tissue following CCH, intermittent fasting (16 h food deprivation daily) could significantly reduce the expression levels of cleaved caspases-1/-8/-11 and maturation of both IL-1β and IL-18, inhibit proptosis and improve cognitive impairment, suggesting the therapeutic effect of non-pharmaceutical intervention. This evidence concerns the gene CASP1 and Cognitive impairment.