The preventive and therapeutic effects of PBM affixed to the exposed skull of stroke mice model were evaluated, and the results showed that the PBM with 630 nm LED array could significantly attenuate the progression of cognitive impairment in the chronic poststroke phase via regulating AIM2 inflammasome activation and AIM2 inflammasome-mediated pyroptosis (Kim et al., 2022). This evidence concerns the gene AIM2 and Stroke.