Liang et al. found that chemerin was significantly upregulated in the serum, placenta tissue, and umbilical cord blood of the diabetic mother, further study revealed that chemerin-induced diabetic pregnant disease via chemokine receptor-like 2 (CCRL2)-dependent enrichment of chemerin in the brain of offspring, which led to macrophage recruitment, activation of NLRP3/caspase-1 mediated pyroptosis, resulting in cognitive impairment. This evidence concerns the gene CASP1 and Cognitive impairment.