Numerous studies have demonstrated that NLRP3/caspase-1 mediated pyroptosis signaling pathway played a crucial role and was the most common therapeutic target of cognitive impairment (Van Zeller et al., 2021; Li et al., 2022), any blockade of NLRP3/caspase-1 mediated pyroptosis may reverse the incidence or progression of cognitive impairment. The gene discussed is CASP1; the disease is Cognitive impairment.