FOXL2 and blepharophimosis, ptosis, and epicanthus inversus syndrome: In addition, the FOXL2 heterozygous deletion variant p.K150Rfs*121 (c.448_448delA) and its coexisting gene BMP15 act synergistically and contribute to POF in the phenotypic variability of BPES, and this variant leads to polyalanine deletion and truncated protein at 269 amino acids (aa) (127, 128).