The binding of CXCL12 to CXCR4 was accompanied by PI3K/Akt signaling activation, while CXCL12/CXCR4 inhibition synchronously inhibited PI3K/Akt signaling, which directly decreased the MSC transplant treatment effect in the POF model (210). This evidence concerns the gene CXCR4 and premature menopause.