For instance, if neuropathophysiological changes to the nigrostriatal DS are correlated with changes to the cortical cholinergic system48, 49 or to white matter hyperintensities,50 then DAT binding deficits may be a proxy for cholinergic or white matter dysfunction that might directly be leading to cognitive decline.51, 52, 53. The gene discussed is SLC6A3; the disease is Mental deterioration.