KCNJ10 and Huntington disease: In line with this study, Diaz- Castro and colleagues deciphered the link between astrocytic Ca2+ signalling, GLT-1, and Kir4.1 in HD mice model and found that loss in homeostatic functions of GLT-1 and Kir4.1 led to aberrant glutamate and Ca2+ signalling altering striatal MSNs (Jiang et al., 2016).