SLC1A2 and Parkinson disease: Moreover, some of the key symptoms widely expressed in PD brains, including impaired glutamate homeostasis and signalling, and neuronal hyperexcitability (Ferrarese et al., 2001; Iovino et al., 2020; Campanelli et al., 2022) have been observed in astrocytic-specific knockdown of glutamate transporter-1 (GLT-1) in the striatum and SNpc (Zhang et al., 2020; Ren et al., 2022).