Among these, lipocalin 2, an inducible factor that is produced by astrocytes having a mutant TAR DNA-binding protein 43 (TDP-43), RNA-binding proteins fused in sarcoma (FUS) genes, and inorganic polyphosphate (polyp) secreted by mutant SOD1, TARDBP, and C9ORF72 astrocytes, are known to selectively eradicate MNs (Bi et al., 2013; Kia et al., 2018; Arredondo et al., 2022). This evidence concerns the gene TARDBP and Melnick-Needles syndrome.