A previous study showed that angiotensin II promotes cardiac hypertrophy by upregulating the expression and activity of proteasome subunits, resulting in the degradation of angiotensin II type 1 receptor (AT1R)-associated protein, and thus potentiating AT1R-mediated p38 MAPK and STAT3 signaling (48). The gene discussed is STAT3; the disease is cardiac hypertrophy.