ALPK3 and hypertrophic cardiomyopathy: Among the other genes potentially implicated in MVP development there is alpha-protein kinase 3 (ALPK3), which is also associated with non-sarcomeric hypertrophic cardiomyopathy, therefore potentially suggesting an overlap between the myopathic and the valvular pathogenic pathways observed in this condition, where often MV disease is considered a primary phenotypic expression of the disease, together with myocyte hypertrophy (9, 34).