TNS1 and familial mitral valve prolapse: Although knowledge about the underlying genetic mechanisms leading to MVP is still limited and their relevance often remains unclear in sporadic forms, as mentioned above, a recent meta-analysis of six genome-wide association studies including almost 5,000 MVP patients was able to identify 14 genetic loci related to MVP (including LMCD1 and TNS1) and to develop a polygenic risk score potentially able to stratify patients according to their genetic risk profile for this condition (9).