Other loci possibly associated with the development of MVP have been identified on chromosomes 2q35, 17p13, 22q12, and 1p32.3 (9, 27) The first of these loci includes two genes found to be involved in mitral and tricuspid valves regurgitation, namely LIM and cysteine-rich domains protein 1 (LMCD1), regulating cell migration and replication, and Tensin 1 (TNS1), involved in focal adhesion control (27, 30). This evidence concerns the gene TNS1 and familial mitral valve prolapse.