Indeed, in addition to the X-linked forms of MVP, autosomal inheritance is more common, but traditionally only three loci have been identified as associated with familial MVP, namely chromosome 16p11.2-p12.1 [Myxomatous MVP-1 (MMVP1), the first locus identified in 1999], 11p15.4 [Myxomatous MVP-2 (MMVP2), also identified as a potential disease-causing gene], and 13q31.3-q32.1 [Myxomatous MVP-3 (MMVP3)] (9, 15, 26, 27). Here, DCHS1 is linked to familial mitral valve prolapse.