BMI ≥ 30.0 kg/m2, NYHA Class II–IV, LVEF ≥ 50% within the preceding year, no hospitalizations due to HF in the preceding 30 days, high filling pressures or pulmonary hypertension, echo signs of structural heart disease, and elevated NT-proBNP levels. This evidence concerns the gene NPPB and pulmonary hypertension.