SENP2 overexpression in invasive bladder cancer cells, T24, suppresses TGFβ-mediated SMAD2/3 phosphorylation, downregulates the expression of mesenchymal markers N-cadherin and fibronectin, and inhibits epithelial to mesenchymal transition (274). The gene discussed is TGFB1; the disease is urinary bladder carcinoma.