However, it is possible that d-flow and cancer therapy accelerate premature senescence through p90RSK-driven posttranslational modifications of TERF2IP and disruption of the Shelterin complex, which is formed by TRF1, TRF2, TIN2, TPP1, POT1, and TERF2IP/RAP1 (121, 122). Here, TPP1 is linked to cancer.