Our model consists of three major components: (1) a set of PDEs governing the diffusive dynamics of the nutrients, the vascular endothelial growth factor (VEGF), and cancer drug compounds, (2) an off-lattice, center-based ABM with spherical agents for the tumor cells governed by a cell cycle, and (3) another off-lattice, center-based ABM with cylindrical agents describing the vasculature and sprouting angiogenesis. This evidence concerns the gene VEGFA and cancer.