A literature search was performed on 14 April 2020 (updated on 10 October 2022) in the PubMed and EMBASE databases (accessed through the Ovid database) using the query string “omalizumab AND asthma AND immunoglobulin E/IgE” to compile a list of studies that reported use of omalizumab in patients with high IgE. Here, IGHE is linked to asthma.