One study reported IgE levels of 464 IU/mL in patients with mild asthma and 1045.32 IU/mL in those with severe asthma;18 similar findings were reported in the TENOR and other studies.20, 21, 22 Although studies generally report median IgE levels of approximately 100 IU/mL to 300 IU/mL in patients with severe asthma, it has been documented that some patients in these studies had IgE levels of 1000 IU/mL or greater (up to 3000 IU/mL).18 Here, IGHE is linked to asthma.