IgE levels can also reach extremely high levels (>1500 IU/mL) in other diseases that may easily overlap with asthma, which we call co-morbidities or multi-morbidities like atopic dermatitis, allergic bronchopulmonary aspergillosis (ABPA), allergic rhinitis, food allergy and nasal polyposis.13 The gene discussed is IGHE; the disease is asthma.