In a study of 11 children and adolescents being treated at The Children's Hospital of Philadelphia, omalizumab was found to be safe and effective with sustained improvement in asthma control and reduction in hospitalizations in patients with severe asthma and high IgE levels (up to 4320 IU/mL); of note, 7 patients had IgE >1500 IU/mL.33 This evidence concerns the gene IGHE and asthma.