IGHE and asthma: In an analysis of the Severe Asthma Molecular Phenotype cohort from Paris in children (n = 45) with multiple allergic comorbidities and high total IgE levels (mean 1871 IU/mL; n = 18), omalizumab was found to be highly effective with a complete and rapid response in terms of improvement in asthma control, lung function, and reduction in frequency of severe exacerbations by more than 50%.51