POMC and neoplasm: The criteria for NS remission after treatment are as follows: (1) ACTH < 200 pg/mL two hours after the morning dosage of glucocorticoids, (2) tumor size less than 10 mm and ACTH less than 200 pmol/L following the cessation of glucocorticoid replacement therapy for at least 24 hours, (3) ACTH less than < 70 pg/mL two hours following the morning glucocorticoid dose and no signs of tumor development, and (4) ACTH less than 200 pg/mL after 24 hours of no glucocorticoid replacement medication and no tumor on MRI [5,31].