The silencing of circGFRA1 can enhance ferroptosis through the circGFRA1/miR-1228/AIFM2 axis (Bazhabayi et al., 2021) and inhibit the proliferation, infiltration, and metastasis of HER2-positive breast cancer cells (Bazhabayi et al., 2021). The gene discussed is AIFM2; the disease is breast cancer.