FZD3 and esophageal squamous cell carcinoma: Knockdown of circPVT1 can inhibit the Wnt/b-catenin pathway in ESCC cells, significantly increase the expression levels of ROS and ferroptosis-associated parameters, and significantly reduce the expression of GSH, GPX4, and SLC7A11; these effects can be significantly reversed by the addition of an miR-30a-5p inhibitor and by FZD3 overexpression (Yao et al., 2021).