More than 20 circRNAs have been reported to inhibit ferroptosis by acting on GPX4, system Xc-, FSP1, lipid metabolism, and other pathways and play important regulatory roles in the progression of many diseases, including various cancers, diabetic nephropathy, polycystic ovary syndrome, and myocardial infarction. Here, AIFM2 is linked to polycystic ovary syndrome.