MAPT and Alzheimer disease: Cumulative studies have recently paved the way to the recognition of neuroinflammation as an important co-actor in AD pathology, playing synergically with Aβ and p-tau cascades (Cribbs et al., 2012; Gomez-Nicola and Boche, 2015; Kinney et al., 2018; Knezevic and Mizrahi, 2018; Thakur et al., 2023).