LGALS3 and neurodegenerative disease: In particular, data from single cell transcriptomic analyses have shown that upregulation of galectin-3 is a shared feature among different populations of specific neurodegenerative disease-associated microglia, including AD (Holtman et al., 2015; Butovsky and Weiner, 2018; García-Revilla et al., 2022; Mijailović et al., 2022).