Donepezil, rivastigmine, and galantamine are cholinesterase inhibitors used to treat mild to moderate symptoms, whereas memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used to treat moderate to severe AD symptoms (Birks and Harvey, 2018; Li et al., 2019; Thancharoen et al., 2019). This evidence concerns the gene BCHE and Alzheimer disease.