NOP2 and breast carcinoma: For instance, NOP2 expression is overexpressed in breast cancer, gallbladder carcinoma, and lung cancer.17–19 The altered expression of NSUN2 has been widely linked to breast cancer, esophageal squamous cell carcinoma, or gastric cancer and correlated with the prognosis of patients.14,20,21 Mechanistically, m5C modification is frequently enriched in oncogenic pathways in bladder cancer.14 Intriguingly, the dynamic variation of m5C RNA methylation guarantees its rapid response to environmental stimulation, indicating its potential role in cancer therapy.