Analyses of molecular alterations of ERK5 in different tumor types using the TCGA datasets (n = 10953 patients from 32 studies) available in cBioPortal (accessed March 25, 2022) showed sarcoma as the top-ranked cancer type, with molecular alterations in a total of 9.02% of cases (Fig. 2a). This evidence concerns the gene MAPK7 and neoplasm.