Considering that the incidence of that sarcoma subtype in the general population is 0.8-1 new cases per 100,000 per year, the 10,000-fold increase in incidence in our mouse model demonstrates that the activation of the ERK5 pathway is capable of promoting sarcomagenesis and opens the possibility of exploring the relevance of this pathway in human sarcomas. This evidence concerns the gene MAPK7 and sarcoma.