For instance, IL-17 promotes the development, tumor infiltration and immunosuppressive activity of myeloid derived suppressor cells (MDSCs),494,495 TAMs,496–498 and pro-tumor neutrophils.499,500 IL-17 also constrains the cytolytic activity of NK cells and CD8+ T cells by inhibiting IL-15-mediated cell maturation501 and recruiting neutrophils,502 respectively. Here, CD8A is linked to neoplasm.