For instance, Eomes and T-bet are dually required for Tex cell generation.334 Eomes expression is elevated in tumor-infiltrating CD8+ T cells and high level of Eomes promotes exhaustion.388,389 But high expression of T-bet was found associated with Tpex and effector-like Tex subset.334,390,391 In addition, TF NFAT family which has a well-established role in mediating T cell activation when partners with AP-1,392 has been shown to regulate Tex cell differentiation. The gene discussed is CD8A; the disease is neoplasm.