While NSAIDs and SAIDs are effective for pain relief and inflammation inhibition, DMARDs are mainly reducing the tissue damages caused by severe inflammation.1073 In recent decades, biological drugs targeting inflammatory cytokines, receptors and signaling molecules have been developed and displayed great effectiveness.652,1074 Among all, Th1- and Th17-associated cytokines, such as TNF-α, IL-12, IL-6, IL-23, and IL-17, are critical for the development and pathogenesis of autoimmune diseases, thus, have been extensively studied and developed for treating multiple autoimmune diseases. This evidence concerns the gene IL17A and autoimmune disease.