The CNSs in Foxp3 locus are critical for Foxp3 transcription and are associated with autoimmune diseases.904–906 Methylation of Treg-specific demethylation region (TSDR)—a highly conserved CpG motif within CNS2—destabilizes Foxp3 expression and disrupts the suppressive activity of Treg cells.899,907 Apart from epigenetic regulation, Treg cell stability/suppressive function are profoundly controlled at transcriptional levels. The gene discussed is FOXP3; the disease is autoimmune disease.