Hence, autoantigen recognition by autoreactive B cells leads to specific killing of pathogenic B cells by CAR-T cells.1091 A number of autoantigens have been identified highly associated with various types of autoimmune diseases.1082 CAAR-T cells expressing pemphigus vulgaris (PV) autoantigen desmoglein-3 (Dsg-3) and muscle specific kinase (MuSK) have been tested in phase I clinical trials for patients with mucosal-dominant PV and MuSK-myasthenia gravis, respectively1092,1093 (Table 5). Here, DSG3 is linked to acquired polycythemia vera.