In comparison to patients with IE, 8 genes (such as CXCL1, LCN2, FGR) from neutrophil degranulation pathway were directly associated with 12 microbial genera (including 11 negative and 2 positive correlations) and 5 genes from synaptic transmission and signaling (DRD3, SNCAIP, GFAP, HAP1, SLC8A3) were observed to be correlated with 6 microbes (including 4 negative and 2 positive associations) in patients with AE. The gene discussed is SLC8A3; the disease is acrodermatitis enteropathica.