Sepsis is defined as an initial hyper-inflammatory response to systemic infection associated with a subsequent immune suppression and dysfunction, that can lead to multiple organ failure, secondary infections and mortality.11 The onset of sepsis is characterized by leukocytosis (marked increase in neutrophils and monocytes) in the first 2–4 days, followed by a state of lymphopenia as a result of apoptosis (drastic reduction of B cells, CD4+ and CD8+ T cells). Here, CD8A is linked to Sepsis.