CD4 and Sepsis: Besides MyD88,36 STING may associate with the membrane proximal/cytoplasmic domain of MHC II, probably through CD79, in APC cells.41 STING was also required for CD4/MHC II reverse signaling, since sCD4 no long improved the survival rates of LPS sepsis (Fig. 5j), nor inhibited TLR4 inflammation in eithr STING−/− mice (Fig. 5k) or STING−/− macrophages in vitro (Fig. 5l).