As preclinical studies also reported various potential effects of sevoflurane on the RAGE and RhoA/F-actin pathways in cells of the central nervous system [23, 24] and as the RAGE pathway plays a pivotal role in epithelial injury and repair during ARDS [3, 25–28], we further hypothesized that the effects of sevoflurane on lung epithelial permeability could be, at least partially, mediated by RAGE. The gene discussed is AGER; the disease is acute respiratory distress syndrome.