CD4 and COVID-19: Evidence demonstrates higher susceptibility to severe COVID-19 in PLHIV with uncontrolled infection due to the lower CD4+ T cells count in these patients.[3-6] There is evidence that the SARS-CoV-2 binds to CD4+ T-cells via the Angiotensin-Converting Enzyme 2 (ACE2) receptor, and it replicates in a wide range of T-helper cells.