Disruption of the circadian clock has been linked to high cancer incidences and accelerated tumor growth rates.[12, 13] Disruption of circadian rhythms in cancer cells in promoting metastasis has recently been reported.[14] For example, BAML1 promotes human cancer cell proliferation, migration, survivals, and invasion,[15, 16, 17, 18] which may involve interactions between cancer cells and stromal cell interaction in the tumor microenvironment (TME).[19, 20, 21, 22, 23] However, the impact of circadian disruption in cancer hosts and TME on metastasis remains unexplored. Here, CLOCK is linked to cancer.