The percentage of animals with pulmonary metastases in TGF‐βR1 inhibitor‐treated tumor‐bearing in Bmal1−/− mice was identical to those in tumor‐bearing Bmal1+/+ mice (Figure 7A), consistent with TGF‐β signaling being responsible for the increased metastasis in CRC tumor–bearing Bmal1−/− mice. This evidence concerns the gene BMAL1 and colorectal carcinoma.