Immunohistochemical analysis demonstrated that CRC tumors in Bmal1−/− mice contained increased stromal fibroblasts, including positive structures of fibroblast activation protein (FAP), α‐SMA, DESMIN, platelet‐derived growth factor receptor alpha (PDGFRα), and platelet‐derived growth factor receptor beta (PDGFRβ) (Figure 1F). Here, DES is linked to colorectal carcinoma.